Influenza is dependent on temperature and humidity.docx

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University of Toronto St. George
Molecular Genetics and Microbiology
Richard Brown

Influenza is dependent on temperature and humidity - Airflow is permitted - Different humidity levels at 25 degrees - NOT TRANSMITTED WHEN IT IS SUPER HUMID - DRIER BY 20-25% IS BETTER - Really hot and low humidity -> no transmission - Humidity is opposite to what we expect - Temp seems important - Cold and dry seems to be the best conditions of transmission (outside winter) - Increasing humidty decreases efficiency - Room temp (like inside) + dry => REALLLY WELL (inside winter) - 50% humidity = transmission is terrible; increasing humidity some more is better (more stable?), but really humid you get NADA (falling with the airborne droplets?) o Like the summer of NA? o Cold and dry seasons are flu season - What about the tropics? - Only route is CONTACT transmission - Not travelling through humid air because the condensation is pulling down the virions with gravity - What about the expected half-life… - enveloped don’t last as long C. Li et al. J Virol. 2011 85:21 - cytokine storm - expression of 12-13 hundred genes has been altered - alveolar - difference in the effect of H5N1 rel
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