PCL200H1 Lecture Notes - Lecture 9: Chronic Obstructive Pulmonary Disease, Major Depressive Disorder, Psychomotor Retardation
12 Dec 2019
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Pcl200 lecture 9: drugs for depression and anxiety. Co-morbidities: co-morbidities, anxiety, chronic obstructive pulmonary disease, parkinson"s disease, diabetes, chronic pain and somatic disorders heart disease. Epidemiology of depression: prevalence varies and is in uenced by: age gender, marital status, ses education in a study in ontario of 12,700 people, the twelve month prevalence of depression, highest in 12-24 age group, lowest over 65. 3-4 weeks to see improvement: another 3-4 weeks to reach full improvement. Neuroimaging studies: volume reduction in medial prefrontal cortex, lateral prefrontal cortex, striatum, amygdala ( ), hippocampus, more functional activity in prefrontal cortex. Monoamine hypothesis of depression: reserpine (blocks vmat2 - lling of monoamine vesicles) causes depression. Tryptophan (amino acid) depletion diet - depressed patients responding well to antidepressants - caused relapse into depression this diet does not affect people without history of depression or in family.
