PCL102H1 Lecture Notes - Lecture 3: Tumor Suppressor Gene, Metastasis, Breast Cancer
31 Jan 2019
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Document Summary
In canada 1 or 3 individuals will get cancer and 1 in 4 will die from cancer. Cancer is organized based on the tissue/organ of origin and mechanism of growth dysregulation (i. e. which pathways have lost control) Goal: design drugs to re-establish control in situations where a particular control mechanism is dysregulated. Cancer frequently involves dna changes as mutations these mutations manifest as differences in base pairing of. Dna (e. g. instead of t there is a) Dna mutations can lead to dysfunctional proteins. Cancer cells invade surrounding tissues and blood vessels then cancer cells are transported by the circulatory system to distant sites, lastly, cancer cells reinvade and grow at a new location (i. e. metastasis) Malignant tumors: tumor cells grow locally and cannot spread by invasion or metastasis. Benign tumors: cells invade neighbouring tissues, enter blood vessels, and metastasize to different sites.
