PCL102H1 Lecture Notes - Lecture 12: Hippocratic Oath, Thalidomide, Morning Sickness
26 Feb 2020
School
Department
Course
Professor
Document Summary
Pcl lecture 12: drug safety and preclinical models. First - do no harm: primum non nocere - latin, hippocratic oath guiding principle for physicians. Thalidomide: used for morning sickness kids born without limbs said placenta stopped drugs from transferring - not true. Frances kelsey - worked for us fda decide on safety of thalidomide federal award for ciivl service - her exceptional judgement prevented birth defects. Time involved: chronic exposure studies in animal models. Types of toxicity endpoints: death of proportion of cells/organisms, surrogate measures of organ toxicity by measuring blood or urine pathology (microscopes) February 13/2020 changes in cell number remaining after drug treatment the more drug we add, the more cell its killing off. From this type of data, calculate how much drug is needed to reduce cell by 50% that is how we rank toxicity. Visualizing toxicity: units: mg of drug per kg of organism calculate how much drug is needed to reduce cell population by 50%
