PCL102H1 Lecture Notes - Lecture 10: Data Mining, Prostaglandin, Macromolecule
12 Feb 2016
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Week #4: lecture 10, 11: target identification and target validation. Target identification a macromolecule (usually a protein) that is central to the disease mechanism; if we modulate protein with drug we can improve health status of patient. Molecule involved in medical problem that is acted on by a drug to stop that disease (aspirin stops molecule cox (drug target) from working; without cox there is no pain) Nucleic acids (hard to find potent compounds) Most drugs bind to proteins, modify their activity shapes matter. Receptors: receive and transmit chemical signals by binding to ligands; drugs normal inhibit receptors by binding to the receptor and have similar shapes to ligands. Mostly cell surface proteins: g-protein coupled receptors, ion channels. Extracellular signalling molecule activates cell surface receptor receptor alters intracellular molecules to generate a response; often a second messenger mediates signalling inside cell. Receptor is a biological molecule to which a drug binds in order to produce an effect.
