PCL201H1 Lecture Notes - Lecture 1: Pedanius Dioscorides, Alkaloid, Digitoxin
Document Summary
Importance of pharmacology: what is pharmacology, a brief history of pharmacology. 3: aspects of pharmacology, pharmacokinetics, pharmacodynamics, understanding pharmacology, careers in pharmacology. 40 volumes of medicinal and toxic plants, antidotes: egypt: ebers papyrus (1500 bc) 700 drugs in 800+ formulas: greece and roman empire, hippocratic corpus (5th century bc- 2nd century ad) Rejected divine/spiritual causes and treatment of disease. Doctrine of the four humors (blood, phlegm, black bile, and yellow bile: de materia medica (pedanius dioscorides, 50-70 ad) Each disease has a unique cause for which there is a specific remedy. Remained in use until 1600s: medieval europe and the islam, the canon of medicine (avicenna, c. 1025) Set the standards for medicine, an authoritative reference as late as the. Foundation for experimental testing of drugs: late 18th-19th century, advances in physiology, pathology, and chemistry provided the foundation for pharmacology (focus on botanicals, ex. 1: focus was on isolating and understanding the effects of natural substances.
