PCL201H1 Lecture Notes - Lecture 4: Aspirin, Receptor Tyrosine Kinase, Second Messenger System
14 Sep 2016
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Lecture 4 drug receptor interactions: determine and understand the interaction between chemicals and receptors. Models: examine the nature of drug receptor interactions, become familiar with signal transduction cascades and how they are manipulated by drugs. Enzyme activity: determine and understand the interaction between chemicals and receptors, most drugs interact with proteins, reversible interactions have weak bonds, irreversible interactions have strong bonds and are usually unfavorable (e. g. aspirin, anti-tumor drugs) Models: drug-receptor interaction is similar to ligand-receptor interaction and can be modeled by the lock and key model. Antagonist: jams the lock: examine the nature of drug receptor interactions, nature of the interaction. Receptors are proteins/enzymes that participate in intracellular and extracellular signalling. Can be endogenous (hormone) or exogenous (drug) Effector molecules are activated by the signal and begin the biological response. E. g. adenylyl cyclase of the gpcr: drug-receptor interaction. One enantiomer may bind to the target site and initiate the desired response.
