PCL201H1 Lecture Notes - Lecture 6: Lipophobicity, Circulatory System, Bioavailability

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL201H1
• Professor: all

Document Summary

Lecture 6 drug administration: overview and important considerations in drug administration, examination of various routes and techniques of drug administration, topical, percutaneous/transdermal, gi tract (sublingual, oral, rectal, pulmonary, injection (sc, im, iv, ia, ip, selection of route. Route of administration: the method by which the drug is introduced into the body: any drug (except those that act topically) must be absorbed into circulation. Must consider: physiochemical properties of the drug, target site, systemic vs. local. Local: drug stays at site of administration (topical: speed and duration, bioavailability. The proportion absorbed from the site of administration that reaches the circulation unchanged, depends heavily on route of administration. 100% for drugs given iv and less for other methods (e. g. oral) Reduced if incompletely absorbed from site of administration or first- pass metabolism. First-pass metabolism: metabolism of the drug in the liver before reaching general circulation.