PCL302H1 Lecture 4: Lecture 4 - Non-Protein Drug Targets.pdf
28 Sep 2014
School
Department
Course
Professor
Document Summary
Drugs acting at sites that are not proteins. Most diuretics act by inhibiting na+ reabsorption by transporters and channels, or by inhibiting enzymes that influence na+ exchange. Sodium reabsorbed at these 4 sites, and water follows sodium. In most cases, diuretics are drug do act on protein targets. Sugar molecule, can be a given at high dose to change the osmolarity of the circulation, and of the urine. capillary: primary renal effect is in the proximal tubule, hyperosmolarity prevents na+ reabsorption. In the absence of mannitol, sodium get reabsorbed and transport back to the blood stream, in the presence of mannitol, sodium is not reabsorbed. Osmotic diuretics: administered intravenously, produce acute vascular hyperosmolarity, a later increase in renal tubular hyperosmolarity causes increased fluid flow and excretion of na+ and water, ultimately decreasing vascular volume, side effects: hypokalemia and acute intravascular volume overload.
