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Pharmacology (260)
PCL201H1 (59)
Worlsey (24)
Lecture

Lecture 21 Variability – Role of Pharmacogenetics

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Lecture 21 VariabilityRole of PharmacogeneticsPrescribed drugs are generally effective in about 50 of patients Inappropriate prescriptionsadverse reactions ADRsdeathCost of treating ADRsCost of medications themselvesCurrent trial and error method of drug prescribingGneneticallyenabled personalized medicineUse genetic technology to develop better medications predictive genotype tests to determine ideal dose drug in right patient at right timeVariation in drug responseGenetic and environmental factors contribute to ADMEPharmacogenetics study of influence of genetic factors on response to and toxicity of foreign chemicalsPatients with same diagnosis may not be homogenous may require different treatmentsNeed technology to identify segregation of responders who are not predisposed to toxi
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