PSL300H1 Lecture Notes - Lecture 7: Toxicodendron Radicans, Water Intoxication, Catabolism
Document Summary
Adrenal gland: epinephrine, aldosterone, cortisol, pituitary diseases. High levels of avp, but receptor not responding. Release of vasopressin is reduced bc of this. Weight loss: no insulin ; frequent urination: high plasma glucose, high blood osmolarity ; thirst&high resp rate: ketosis & low ph ; low bp: dehydration due to water loss. Medulla acts as extension of sympathetic nervous system. Epinephrine is usually secreted bc it is the end product of the chain. Adrenergic receptors are responsible for the glucose release in liver and fatty acid release. Liver: glucose release via enhanced glycogenolysis: fat: fatty acid release, heart: increases force of contraction, intestine: muscle relaxation, intestine, skin, kidney: arteriole constriction. Arteriole contraction (via alpha receptors: brain: increases alertness. Arteriole contraction - you want more in skeletal than smooth (beta-2 receptors) Caffeine stimulates cns adrenergic receptors - affects beta-2. Alpha 2 is inhibitory - counteracts beta receptor, and inhibits adenylyl cyclase. Alpha 1 is stimulatory, but works on another pathway.
