PSL300H1 Lecture Notes - Lecture 6: Glucagon Receptor, Receptor Tyrosine Kinase, Diabetes Insipidus
Document Summary
The role of the pancreas in glucose homeostasis. A 38-year-old woman with extreme thirst and frequent urination (symptoms started 3 months ago) Drinks 10-15 large glasses of water + several cans of soda over 2-3 hours. Physical exam: appears normal, 5 ft tall, 128 lbs, blood pressure. Homeostasis: metabolic processes (sum of all chemical reactions in the body) Basal metabolic rate (bmr) = an individual"s energy expenditure when resting, comfortable temperature, fasted. Neurons and red blood cells depends on glucose and ketone bodies. 200g variable (1kg = 4000 kcal) (1kg = 9000 kcal) variable. It"s approximately 1 hr after lunch, assume you ate a turkey sandwich: 46g carbs, 8g sugar, 18g protein, 4. 5g fat. How long will it keep the brain fueled? (assume no fat/protein contribution) Anabolic state: state where you"re building the storage. Driving the synthesis of glycogen, converting hdl ldl-c. Mobilize triglyceride and glycogen (glycogenolysis ) and protein (gluconeogenesis - de novo production of glucose )
