PSL300H1 Lecture 8: Lecture 8 - Metabolic regulation _ Growth
Document Summary
Growth hormone: synthesis & regulation actions on bone and metabolism. Thyroid hormone: synthesis & regulation actions on development and metabolism. Remove tumor by surgery (then permanent cortisol replacement. Prescribe medications to control cortisol production (inhibitors of 11beta hydroxylase ) Peak bone mass is between 20-30 years of age. The peak of bone formation is higher in male. Take longer to break the bone (but if there is a exogenous impact they can get osteoporosis as easy as women) Growth plates closing towards end of puberty. May contract bone, but no longer able to lengthen it. A gap in bone -- dividing chondrocytes -- secreting cartilage. Amount of bone growth dependent of activity in this region and highly regulated, affected by multiple hormones. Bone growth ceases when epiphyseal plate fuses (a) epiphyseal cartilage in a child (b) epiphyseal lines in an adult.
