PSL300H1 Lecture Notes - Lecture 8: Surface 3, Follicular Cell, Cretinism
Document Summary
Acromegaly: condition where person has too much growth hormone in adulthood. Can cause giants (very tall) or bone thickening. Depends on if gh abnormality occurs before/after fusing of epiphyseal growth plates. Epiphyseal growth plate: location of bone lengthening. Trabecular bone framework & bone marrow (inside, squishy) Mature cell puts down ca2: moves further away from epiphyseal growth plate. Thyroid hormone: abundant especially at birth very important for correct neural development. Cortisol: negative effect on growth: causes relocation of resources to deal with stressor. Gh increase osteoblast activity increase osteoclast activity. Take away bits of bone, to add more bone & repair weak regions strengthens bone. Surge in estrogen: occurs in both males and females. Growth hormone abnormality before epiphyseal closing tall. Growth hormone abnormality after epiphyseal closing bone thickening. Stimulants: sleep, fasting (want to increase glucose concentration in blood, stress (need to localize resources)
