PSL300H1 Lecture Notes - Lecture 2: Lipotropin, Proopiomelanocortin, Exocytosis
Document Summary
Lecture 2: classification of hormones and control of release. Types of hormones: peptide (3 or more amino acids, procesing (connecting, steroid (derived from cholesterol, synthesised only from cholestoerol, made on demand. N- terminal signal sequence sends the protein to the rer. Processing occurs in golgi- hormone can get glycosylated, folded, form. Signal sequence cleaved off as protein is made disulphide bonds etc. Several copies of the same hormone peptides and signal sequence. More than one type of hormone enorphin and signal sequence e. g. prepro trh gives 6 trh (3 amino acids each), other. Formation of disulphide bonds, glycosylation, removal of c-peptide: released by simple diffusion, water insoluble. Cholesterol converted to aldosterone and cortisol in adrenal cortex, but to estradiol in the ovaries: amine (derived from single amino acids, only synthesized from tryptophan or tyrosine, trp: melatonin (behaves like peptides/steroids) Made in pineal gland (also in gi tract, leukocytes, other brain regions)
