PSL301H1 Lecture Notes - Lecture 18: Respiratory Center, Opioid Overdose, Internal Intercostal Muscles

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Michelle French

Document Summary

Activate internal intercostal muscles for expiration via phrenic nerve. Activate external intercostals and diaphragm for inspiration via spinal cord: diaphragm by phrenic nerve, upper airway by hypoglossal nerve, scalenes by cervical nerves. Pontine respiratory group: vrg, nts, drg the sudden, unexpected, non traumatic, and non drowning death of patients with epilepsy, respiratory distress/cardiac asystole. Ictal or postictal hypoventilation -> central apneas: cns shutdown due to seizures, brainstem seizures, postictal 5-ht neuron inhibition prebotzinger complex (has pacemaker neurons) Yes -> decrease respiratory rate: hypoventilation or cessation of breathing, cardiac arrhythmia and low bp. Give naloxone which is an opioid receptor antagonist: ampakine: modulator of ampa, serotonin: h-ht2a receptor agonist. Neurodevelopmental disorder of the grey matter of the brain the exclusively affects females: loss of motor function (hands, walking, seizures, breathing difficulties while awake. Mutation of methyl cpg binding protein (mecp2) which is needed for brain development and found in the prebotzinger complex.