PSL301H1 Lecture Notes - Lecture 4: Wild Type, Vertebral Artery, Brainstem

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Christine Wong

Document Summary

Recorded spikes show changing carbon dioxide levels increase the amount of spikes. How do co2 chemoreceptors work? v proton-sensing g-protein coupled receptor 4 (gpr4) located in. Rtn v sense extracellular ph lower than 7 v this is the node of another group that was identified: can identify proton sensing g-protein coupled receptors 4 (gpcr4) located in the rtn. This senses extracellular ph lower than 7 v if there are more protons, then ph decreases. Psl301 human physiology ii v experiment: knock-out animals lacking this gpcr4: blue = wild type. Ventilation increasing in a normal fashion: red = ko. Very small increase in ventilation in response to carbon dioxide. Other receptors are also sensitive to carbon dioxide, accounting for the small increase seen. The vertebral arteries: capillaries go inward so they can perfuse the brain tissue well, the serotonergic neurons (green) are chemosensitive. Around ph 7. 4-7. 2: in contrast, the rtn senses bigger changes.