PSY100H1 Lecture 8: Lec o8.pdf
2 Dec 2014
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Lec o8- sleep and waking. Jet lag is worse when travelling east. Suprachiasmatic nucleus is the master. The cellular basis of circadian rhythms. Per, tim, and clock (genes and their protein products) Biochemistry and circadian rhythms. Scn regulates and responds to this hormone secreted by pineal body. This hormone also fluctuates with patterns of waking and sleeping. Also secreted during times of stress. Stress- induced high cortisol levels during the night are correlated with poor sleep quality. In fruit flies a gene called clock is responsible for the expression of the. Clock protein, which triggers production of the protein per and tim proteins. Clock then initiates the production of tim and per once again (cycle). Early in the day, low levels of. Per and tim seize to inhibit clock which then produces more per and tim and their levels then rise. By late afternoon, their levels are increasing and early evening, tim and per inhibit clock and their production seizes.
