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Lecture 6

Lecture 6

3 Pages
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Department
Psychology
Course Code
PSY100H1
Professor
Michael Inzlicht

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Lecture 6September 29
Manipulating Action Potentials
1)Alter the amount of neurotransmitter release
-Amphetamines cause massive dumping of catecholamines, (e.g. dopamine)
increasing the amount of neurotransmitter released.
2) Block the removal of the neurotransmitter from the synapse (SSRIs)
(cocaine blocks reuptake of Dopamine in nucleus accumbens)
3) Make the post-synaptic receptors more or less sensitive (e.g. nicotine
enhances sensitivity of the post-synaptic receptor for dopamine) desensitization
occurs
Remember, the synaptic cleft connects the terminal buttons of one neuron, to the
dendrites of another
Key Neurotransmitters and their Primary Functions
Amino Acids:
General excitatory and inhibitory
Glutamate:
Most prevalent excitatory neurotransmitter in the CNS (learning and
memory)
GABA:
Most prevalent inhibitory neurotransmitter in the CNS (inhibition of
seizures, anxiety disorders) If you reduce GABA activity, you will enhance
Dopamine activity
Acetylcholine:
CNS functions: complex mental processes (memory), Alzheimers patients
have low levels of Ach.
Epinephrine and Norepinephrine
Arousal and alertness
Heightened attention
Depression (not enough N), anxiety (too much N)
Serotonin:
Mood (and therefore depression, anxiety, various emotion and motivation
problems)
Impulse control
Dreaming
Dopamine:
Reward
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Description
Lecture 6 September 29 Manipulating Action Potentials 1) Alter the amount of neurotransmitter release -Amphetamines cause massive dumping of catecholamines, (e.g. dopamine) increasing the amount of neurotransmitter released. 2) Block the removal of the neurotransmitter from the synapse (SSRIs) (cocaine blocks reuptake of Dopamine in nucleus accumbens) 3) Make the post-synaptic receptors more or less sensitive (e.g. nicotine enhances sensitivity of the post-synaptic receptor for dopamine) desensitization occurs Remember, the synaptic cleft connects the terminal buttons of one neuron, to the dendrites of another Key Neurotransmitters and their Primary Functions Amino Acids: General excitatory and in
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