PSY492H1 Lecture Notes - Lecture 4: Morris Water Navigation Task, Nmda Receptor Antagonist, Grin2B
Document Summary
Evoked field potentials display vary distinct characteristics: fiber volley: activity of presynaptic neuron, slope: excitatory postsynaptic potential (epsp) Important to note: when looking at efp graph, the slope can be up or down and this can mean either depolarization or hyperpolarization depending on where the recording electrode is located. If extracellular = depolarization slope will be downwards, this is because outside is becoming more negative due to flow of positive ions into cell. If intracellular = depolarization slope will be upwards because inside is getting more positive (archetypal example of depolarization usually shows this type of graph) Experiment: first use test stimulus (stimulus enough to invoke 50% response rate from postsynaptic neuron). Next, use high-frequency stimulation (hfs) to induce ltp: result: afterwards you see increased response to test stimulus. Low-frequency stimulus will induce the opposite affect and cause depressed response (as opposed to potentiated) Several antagonist studies have found that nmdar and ampar are key receptors in mediating ltp.
