PSY492H1 Lecture Notes - Lecture 6: Protein Synthesis Inhibitor, Antidromic, Immediate Early Gene
Document Summary
Ltp = after high frequency stimulation, epsp increases. Lfs = reduction of epsp amplitude, value becomes smaller, reduction of slope and. Just like memory, ltp exists in short term for and long term form, s-ltp and l-ltp respectively. If researches apply strong hfs it creates an l-ltp, stays stable for 2 hours. When researchers reduce amplitude of hfs which becomes lfs, it generates an s- If protein synthesis inhibitors anis was administered before induction of ltp, even when hfs is applied, s-ltp is there but l-ltp is not observed. S-ltp can be induced without synthesis of new proteins but stable l-ltp, stable protein synthesis is necessary. Last week, found that stm is not dependent on protein synthesis, but ltm is. When hfs applied, first mrna transcribed in nucleus, and translated into new protein. Actually, some mrna already exists in dendrites before hfs is applied, Ca++ influx occurs at synapse but transcription/translation occurs in nucleus = distance problem.
