BIOL 465 Lecture Notes - Lecture 18: Carcinoma, Cell Nucleus, Metastasis
30 Jul 2017
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Document Summary
Ability to destroy the basal membranee by proteases. Ability to separate from adjacent cells - loss in adhesion. Multiple steps in the ways the cell metastasize. This is what separates a tumour/ cancer cell from neoplastic cells. Complex, heterogenous, disorganized - variable and evolving cell populations. Macroscopic appearance(in pathology): light mass sitting on the surface of tissues. Carcinoma: no normal structures, replaced by cells and the tumour cell nuclei are much larger, new chromatin pattern ( distinguishes between normal and carcinomas) Cross section of a breast tumour > shows a heterogenous cell with different types of cells in near by diagnostic process by pathologist. Assessment of clinical presentation, histological and molecular features using : gross assessment ( looking with naked eye),light microscopy, sub cellular features( taking couple of sections and stain) , phenotypic features9 looking at genetic expression) Biopsy: two types > fine needle (cytology) and core biopsy (pathology)
