Anatomy and Cell Biology 2221 Lecture Notes - Lecture 11: Nmda Receptor Antagonist, De Novo Synthesis, Syringe Driver
27 Feb 2015
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Both depend on ca2+ elevation in intracellular uid ! Ca2+ might come through nmdar or through speci c types of receptors, vg ca2+ channels, or intracellular stores! To elevate ca2+ you need a depolarization of the postsynaptic side at the same time the presynaptic side releases glutamate ! You can use ltp to explain plasticities that have postulated ! Need two neurones ring at the same time (presynaptic res. Presynaptic released nt and postsynaptic neurone requires an. Ap happens at axon hillock but is passively spread in all directions ! Many dendrites are depolarized by post synaptic ap! Two neurons that re together and wire together express ltp ! Normal synapse, glutamate synapse with ampa receptors, nmdar, and metabotropic receptors ac>vated as much. Basal synap>c transmission nmdar is normally blocked by mg2+ so it"d mainly be by ampar. Metabotropic have rela>vely low a nity or sit further to the side of synapse - aren"t.
