Anatomy and Cell Biology 2221 Lecture Notes - Lecture 19: Substantia Nigra, Lrrk2, Dopaminergic Cell Groups
27 Feb 2015
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Document Summary
Regulates sensorimotor activity, including tone and posture. Components: striatum *, globus pallidum, substantia nigra *, subthalamic nucleus. Works in close proximity to cerebral cortex. Gets information from cortex and processes regulated movement of information: pathophysiology, loss of dopaminergic neurons in the substancia nigra. Lewy body: bowel and bladder problems, sexual dysfunction, pathological markers, loss of dopaminergic neurons in the substantia nigra, intracytoplasmic inclusions (lewy bodies) in the remaining, intact nigral neurons. Proteins that aggregate in these nigral neurons and form deposits. Proteins: alpha-synuclein, parkin & lrrk2: causes, most cases cause is unknown (idiopathic unknown or spontaneous cause, risk factors, age, genetic (2-3% late onset, 50% early onset) Mitochondrion dysfunction increase in reactive oxygen species cause degeneration. Lewy bodies appears more marked in late- onset disease, and in many instances, individuals with late-onset disease have additional age related pathologies (represented as cortical plaques same plaques in. Hva: biochemistry of dopamine (da, synthesized in nerve terminal, uses substrate tyrosine to make.
