Anatomy and Cell Biology 4451F/G Lecture Notes - Lecture 11: Long-Term Depression, Synaptic Plasticity, Long-Term Potentiation
20 Oct 2017
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Document Summary
Different forms of plasticity and can go in different directions augmented or potentiated efficacy can be increased. Or efficacy can be decreased call that synaptic depression. Lots of different names for synaptic potentiation but one name for depression. Can generally distinguish between short term and long term plasticity. Synaptic facilitation and depression, when given synapse is activated twice within a very fast succession there is memory in synapse that we can probe with pulses so if the(cid:455)"re close together (500- All short term plasticities are reversible biochemical processes end at one point eventually calcium accumulation gets reset, or channel gets dephosphorylated etc - reset. Can go both ways potentiation and depression. It lasts hours or days but prof thinks it lasts infinitely = as long as it is not actively reversed. Long term potentiation can be reversed by long term depression but if no mechanism inducing long term depression, the potentiation will just be there.
