Anatomy and Cell Biology 4451F/G Lecture 22: Lecture-22

• School: Western University
• Department: Anatomy and Cell Biology
• Course: Anatomy and Cell Biology 4451F/G
• Professor: All

Document Summary

Lecture 22: neuroinflammation: implication in ad and stroke. There is a loss of brain tissue because a vessel that normally perfuses and gives oxygen rich blood, nutrients, glucose, and other metabolites to that tissue gets blocked for whatever reason. How does a vessel get blocked: blocked locally (build up of plaque in the blood vessel in the brain, blocked in other place other than the brain like the arm or the leg. What happens is that clot becomes destabilized and it dislodges and travels from vasculature and just gets stuck in a brain (cid:448)essel. When vessels get blocked, no blood supply to that tissue, neurons start to die rapidly. Bursting of blood vessel results in loss of blood to that brain area. There are other things that go on: swelling and edema. In either cases, you get rapid cell death and you end up with infarct in necrotic core.