Biochemistry 3386B Lecture 5: Deroo Lecture 5 Hormones

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Objec?ves: review estrogen receptor mechanism of ac4on, iden4fy types of estrogens and estrogen receptors, discuss selec4ve estrogen receptor modulators. Osteoporosis: understand use of estrogens in oral contracep4ves, phytoestrogens, xenoestrogens: bpa & case study. Types/classes of estrogens: steroidal & non- steroidal. Incidence of er muta?ons in the human popula?on: one person! Estrogen resistance caused by a muta2on in the estrogen- receptor gene in a man. Muta4on: cytosine- to- thymine transi4on at codon 157 of both alleles, resul4ng in a premature stop codon. Serum estradiol and estrone concentra4ons were elevated. Glucose tolerance was impaired, and hyperinsulinemia was present. Low bone mineral density due to increased bone turnover. Mueller and korach - 2000. Estrogens & combined oral contracep4ves induce ovula4on. Serms: very important in treatment and preven4on of various diseases and condi4ons. 4ssue in which they act, eg. tamoxifen. Tamoxifen is an antagonist of the estrogen receptor in breast 4ssue via its ac4ve metabolite, hydroxytamoxifen.

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