Biochemistry 2288A Lecture Notes - Lecture 13: Pyruvic Acid, Mitochondrion, Microsoft Onenote
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17 Jun 2016
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Under aerobic conditions, pyruvate produced by glycolysis is transported into mitochondria where it is oxidized to form co2. The outer membrane has many pores are is freely permeable to most solutes of low molecular weight (<5000 da). The inner membrane is impermeable to ions and charged molecules, which can only cross it if a special path is made. The inner membrane is folded to form cristae which greatly increases surface area. The matrix is the space enclosed by the inner membrane. Pyruvate + o2 --> --> --> --> --> co2 + h2o. Decarboxylation of pyruvate to form acetyl-coenzyme a (acetyl- Oxidation of the acetyl of acetyl-coa in the citric acid cycle. Carrier molecule used to transfer the acetyl group to the citric acid cycle. This reaction is irreversible and is the only way mammals can produce acetyl- Pyruvate dehydrogenase complex is an assembly of three enzymes. Competitively inhibited by its produces acetyl-coa and nadh.
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