Biochemistry 2288A Lecture Notes - Lecture 16: Sharepoint, Gluconeogenesis, Acetoacetic Acid

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2288A
• Professor: Chris Brandl

Document Summary

When energy is needed from fat storage, lipases in adipocytes degrade triacylglycerol into glycerol and three fatty acids. The released glycerol is a substrate for gluconeogenesis. Transporters move fatty acid from the blood into the cytosol. https://uwoca-my. sharepoint. com/personal/akalluma_uwo_ca/_layouts/15/wopiframe. aspx?sourcedoc={5e62ed6a-49ad-486b-a23a-ea4b3ec5cbfc}& l The fatty acid is activated with coa in the cytosol. Fatty acyl-coa is transported into the mitochondrial matrix. Carbons are removed from fatty acid two at a time. Produces 1 nadh and 1 fadh2 per cycle. Keeps cycling until the fatty acid is completely oxidized. The net reaction with 2n carbons in matrix. Oxidation of unsaturated fatty acids yields fewer fadh2 and may consume nadph. Oxidation of odd-chain fatty acids yields one propionyl-coa, which enters cac as succinyl-coa. Each fadh2 gives electrons to q to make qh2, but using different protein complexes. Liver mitochondria can convert acetyl-coa to ketone bodies so that it can be transported to other tissues https://uwoca-my. sharepoint. com/personal/akalluma_uwo_ca/_layouts/15/wopiframe. aspx?sourcedoc={5e62ed6a-49ad-486b-a23a-ea4b3ec5cbfc}& l