Biochemistry 3386B Lecture 6: Final Comprehensive Hormone Lecture Deroo Notes
4 Feb 2015
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Testosterone: >95% produced in the. Ar than testosterone testes (men: ovaries & placenta, 0. 3% is converted into estradiol by aromatase (bones & brain, binds ar. The physiological roles of t/dht. Generally anabolic: builds muscle and bone. Prenatally: genital virilizakon, development of male reproduckve kssues, such as tesks and prostate. Prepubertally: promokng secondary sexual characteriskcs such as increased muscle, bone mass. Human genekcs, july 2005: however, other factors from dad"s side are also involved. Chromosome 20 (nature genekcs 40, 1282 - 1284 (2008)) Prostate cancer treatment (hormone therapy: androgen ablakon therapy. Surgical or chemical castrakon: chemical castrakon common. Drugs that prevent the adrenal glands from making androgens, eg. ketoconazole decrease in fsh and lh is achieved through receptor downregulakon. *establishment and maintenance of pregnancy. Prepares the uterus for pregnancy (increases growth of blood vessels: released by the placenta. Maintain uterine lining during pregnancy. Prevents preterm labor by reducing myometrial contrackon. Alveolar development in lactakng breast.
