Biology 1001A Lecture Notes - Lecture 14: Proteasome, Microrna, Ubiquitin
5 Mar 2014
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Document Summary
Basic structure of eukaryotic vs prokaryotic cell with respect to gene expression - Fundamental difference between eukaryotes and prokaryotes with respect to gene expression is the presence of the nucleus in eukaryotes. Structure of eukaryotic endomembrane system with respect to gene expression - The promoter proximal regions are protein binding sites near promoter which when bonded with protein cause the promoter to be more attractive to rna polymerase ii. The promoter is where the rna polymerase ii binds. Rna polymerase ii only finds promoter attractive if proteins are associated with the promoter which is where tata binding proteins come into play. Tata binding protein associate around tata box making promoter more attractive. The enhancer can be quite far away from the rest of the sequence. Protein motifs common in dna binding proteins - Helix-turn-helix dna binding motif: an alpha helix, then turn, then another alpha helix. Lac repressor uses this motif to bind to the operator in lac operons.
