Biology 2382B Lecture Notes - Lecture 10: Coronary Circulation, Pde5 Inhibitor, Diglyceride
Document Summary
Lec 10: function of g protein coupled receptors in cells. K+ channels: gpcrs that regulate adenylyl cyclase. Camp, epithelial cell cl- channels, pka, creb: gpcrs that activate phospholipase c. Ca2+, ip3, dag, pkc, no, cgmp, pkg. Activation of muscarinic acetylcholine receptor and k+ channels in the heart. When acetylcholine bind to its receptor, leads to opening of. Slows the rate of heart muscle contraction. G subunit activates the effector protein (k+ channel) Not using alpha to affect the effector** different than other g coupled receptors. The alpha subunit isnt directly involved in transmitting the signal its the beta-gamma subunit that is. Binds to and activates a k+ channel. This is important to control the rate/intensity of heart muscle contraction. When you open the channel you get depolarization of the cell and externalization of k+ which leads to a slower rate of heart muscle contractions= slow down heart immediately. Is normally associated with the plasma membrane.