Biology 2382B Lecture Notes - Lecture 9: Intermediate Filament, Microtubule, Microfilament

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Cells can move and things within the cell can move. Cytoskeleton roles: organelle/protein trafficking anterograde and retrograde transport, cilia/flagella, mitosis/cytokinesis, muscle contraction, cell adhesion, cell migration, extravasation. Bilogical molecules: biological molecules are 3d have a specific shape and size and take up space, there is no empty space inside of a cell. Because microtubules make up structures such a cilia and flagella: these microtubules can be 100um long these dimers polymerize and form these long structures called microtubules. So microtubule structures can be way longer than the cell: there are different isoforms of tubulin. The main component of microtubules are alpha and beta tubulin. They are both 55kda each they are very similar to each other. When a cell translates the alpha and beta monomer, they almost instantly form a dimer. So this alpha-beta dimer is the basic building block. So if a cell is building microtubules, it is using the dimer.

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