Biology 2382B Lecture 12: Lecture 12
7 Jan 2019
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Document Summary
Transparent: every single cell (959 in adult hermaphrodite and 1031 in the adult male) has been, mapped out, genome fully sequenced, many genetic mutants. Ced-3, 4 and 9 mutations in ced-3 and 4 cause the cells not to die these 2 genes and the proteins they encode are important in triggering cell death in a controlled developmental pathway. Composed of : apaf-1 : apoptotic protease activating factor 1. Cytochrome c (released from mitochondria: apoptosome 1. 4 megadalton wheel of death, dimer of caspase 9, after binding of cytochrome c apaf-1 forms a disk shaped. Cytochrome c binds apaf-1 and this causes the formation of the heptameric structure that in turn will cause a dimer 2 molecules of caspase 9 to bind to the underbelly of the structure that in turn will now activate caspase 9 initiator caspase. Ced3 in c. elegans is caspase 9 in mammals. Ced4 has a similar/function in c. elegans as apaf-1 in mammals.
