Biology 2382B Lecture Notes - Lecture 10: Paclitaxel, Colchicine, Hydrolysis
23 Aug 2016
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The cytoskeleton intricate network of protein filaments that extend throughout the cytoplasm: microtubules (25nm, microfilaments (7-9nm, intermediate filaments (10nm) The cytoskeleton: microtubules (821-859, actin filaments (773-791, myosin and muscle contractions (793-814, intermediate filaments (860-866, cell junctions, cell adhesion and the extracellular matrix (925-965) Membranes and membrane proteins: biomembrane properties and membrane proteins (443-468, membrane transport (473-515, integrating membrane proteins (577-594) Muscle contraction cell adhesion cell migration extravasation keep in mind: Microtubules are very large protein structures compared to other proteins the cytoplasm is filled with other molecules (not empty space) Microtubules are bundles of polymers of and tubulin: each monomer is 55kda each. Tubulin dimer is basic subunit : has polarity: -tubulin (-), -tubulin (+, each dimer is 8nm wide, note: once dimers form, they do not separate into monomers. Microtubules have hollow tube structure: tubulin dimers polymerize into protofilaments, protofilaments aggregate to form microtubule. Microtubules are 25nm in diameter and up to 100s of mm long.
