Biology 3338A Lecture Notes - Lecture 20: Neural Crest, Rho Family Of Gtpases, Pax3

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Gastrulation and neurulation patterns/movements occur differently in different animals. But some principles conserved whether frog, chick or mouse embryo. Neural tube fuses and closes due to n-cadherins and epidermis fuses due to e-cadherins while neural crest cells migrate. Neural crest cells referred to as fourth germ layer as they go on to give rise to many different tissues. Neural crest cells receive mixed signals and thus become migratory right before neural tube closes in mammals (migration occurs at different times in different animals) Transient structure = neural crest cell migrate ie. get out of the way to allow neural tube to close and separate from epidermis. Pluripotent = go on to give rise to different cell types including many neurons and they lose potency as they differentiate. Top shows chick embryo with dorsal axis in middle (white) Different levels of bmps and wnts in different areas lead to different borders.

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