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Lecture 12

Biology 1002B Lecture Notes - Lecture 12: Histone H1, Chromatin Remodeling, Start Codon


Department
Biology
Course Code
BIOL 1002B
Professor
Patrick Mc Donald
Lecture
12

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Biology 1202 B
Lecture Cycle 6 (Lecture 12
Transcription and Translation
Material Covered – DNA Codes for Proteins, Transcription, mRNA
Processing, Mutations
Transcription
Many similaries between DNA replicaon and transcripon – keep them separate
We generally think of transcripon as the !rst step in protein producon
- Funconal products of transcripon also include RNA molecules
Eukaryotic Chromatin Structure
Histones + Charge
- DNA – Charge
- Histones octamer – 2x(H2A, H2B, H3, H4)
Nucleosome
- DNA wrapped around histone octamer
Histone tails are sites of chemical modi!caon
- Chroman remodeling
Histone H1 binding
- 30nm !bre
Further packaging
- Heterochroman –
Densely packed with
proteins (silent) ,
inacve in females
- Euchroman – Loosely
backed (available for
transcripon)
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