Biology 1002B Lecture Notes - Lecture 7: Insertion Sequence, Transposase, Thymine
12 Mar 2016
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Document Summary
About 2500 structural variations including mobile elements, cnv (copy number variations, inversions, etc) About 120000 variations in coding regions and 1000 variants are de novo (new) Mobile elements code for their own mobility (transposase) = cause mutations. Insertion sequence codes for transposases and allows it to move around in bacterial genome. Two insertion sequences can move everything between them (this is a transposane) Eukaryotes have lots of mobile elements (move by recombination) Evolution does not care about mutations in somatic cells. Mutations in somatic cells are not inherited and do not advance evolution. African descent have more variable in their genome than asian or caucasian descent. This is due to the fact that african population is oldest and hast most time for variation. Bases are more stable in one tautomer than the other (keto form of thymine is favored but sometimes it switches) A gc pair where there was a at is a snp.
