Biology 1002B Lecture Notes - Lecture 16: Product Rule, Genetic Drift, Qualitative Variation
14 Mar 2016
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Document Summary
Incorrect base pairs do not fit correctly, thus their oh-end aren"t lined up at the correct place. Dna polymerase will have to remove the incorrect base (with deoxyribonuclease) and add on a correct one before it can continue: mechanism of mismatch repair. A mismatch will create destabilizing h-bonds that distorts the shape of the double helix. Enzymes find these mistakes using the distortion. Enzymes remove a section of the dna containing the mistakes, and dna polymerase fills in the bases again (ligase seals the nicks: difference between insertion sequences, transposons and retrotransposons. Short/small, usually only one gene and a transposase. Has inverted repeat sequences at the end. Has transposase and insertion sequences in their inverted repeat sequences. Dna -> complementary rna -> dna to be inserted. Similar to retroviruses: why mobile elements are considered to be biological mutagens. Change dna: general trends in costs of dna sequencing.
