Biology 1002B Lecture 15: Lecture 15
20 Apr 2016
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Identify various mechanisms for regulation of gene expression as summarized in figure 14. 6. Transcriptional regulation: chromatin remodelling, dna methylation, availability of various activators, efficiency of enhancer/promoter, etc. Translational regulation: mirna silencing, and length of polya tail. Posttranslational regulation: variations in rate of protein degradation (ubiquitin), chemical modification of proteins. Identify characteristics of genetic mosaics. For some genes, the inactivation of either x chromosome in heterozygotes produces different effects in distinct regions of the body. Lecture: reasons why, if identical twin women have sons with identical twin men, the sons will not be identical. The variability in expression of disease risk due to genetic variation. Environmental mutagens, natural mutations in their cells. X inactivation, levels of dna methylation. Gene expression (same genes, but different genes are expressed) Their mobile elements are in different places (as developed from embryo their mobile elements would also move) They would make different gametes. Environmental mutagens they are exposed to.
