Biology 1201A Lecture Notes - Lecture 6: Missense Mutation, Guanine, Transfer Rna

• School: Western University
• Department: Biology
• Course: Biology 1201A
• Professor: Vera Tai

Document Summary

Lecture 6 origins of variation i: new alleles. The nucleotide sequence is not paired correctly. Many mutations may not have huge effect on your genotype since. Point mutations occur when one base changes. Differences in a base single nucleotide polymorphism: tautomeric shifts. The atomic makeup of the compound is the same, but the ordering of the atoms is different (isomer) This can change the amino acids that are produced: deamination. Changes a single base in your dna sequence: oxidation. Oxidative damage changes the base pairing (ex. Thymine dimers will still base pair w/ adenine. Uv radiation can also cause cytosine dimers which will base pair w/ adenine. Silent mutations occur when there is no change in an amino acid. Missense mutation occurs when there is a change in one amino acid. Nonsense mutations result in a premature stop codon (common in pseudogenes) Frameshift mutation, shifts the reading frame so that it is not divisible by 3.