Biology 1202B Lecture Notes - Lecture 12: Polysome, Release Factor, Peptidyl Transferase
28 Feb 2017
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Document Summary
Proteins have ends - polarity, determined by what group is on the end. At the end terminal (first place to be translated) one end has n ternal and the other end has a c ternal trna. Secondary structure: bases frequently modified after they are transcribed. Pairing between 1st 2 bases of codon always precise. First two bases are paired normally according to watson & crick, the third base has a wobble pairing. wobble in pairing at 3rd base in codon: looser monitoring at this position by ribosome. What are the first 3 amino acids of the peptide code by the dna sequence below: met- leu-cys. 2 subunits composed of rna and protein. Peptidyl transferase: ribosome, transfer peptide chain p -> a. Ribosome translocates: peptide chain p site. Stop codon not recognized by a trna: recognized by release factor (rf) No competition from trna allows it to enter a site. Increases the rate of protein production: mrnas are translated many times.
