Biology 1202B Lecture Notes - Lecture 13: Polysome, Release Factor, Protein Quality
10 May 2016
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Document Summary
Ribosomes are the site of peptide synthesis trna. The vehicle that transports amino acids to the ribosomes to be formed into appropriate polypeptides. But when it is incorporated into trna it creates the wobble . But there is not 61 different trnas. Base pairs may not necessarily be paired properly in 3rd position. Are there 61 different trnas: no! Pairing between 1st 2 bases of codon always precise. Wobble in pairing at 3rd base in codon. Looser monitoring at this position by ribosome. Wobble in 3 rd position of the codon. Nontemplate: 3" -tctactgtatcgtatc- 5": met-pro-tyr, met-leu-cys, glu-val-his, met-leu-trp. Translation requires energy in the form of gtp. Peptide chain is elongated through the p site. Stop codon not recognized by a trna. No competition from trna allows it to enter a site. In the image of bacterial transcription and translation below, which ribosome has been translating mrna for the longest period of time: a, b, c, d.
