Biology 1202B Lecture Notes - Lecture 9: Cellular Respiration, Oxidative Phosphorylation, Intermembrane Space

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Biology 1202b: lecture 9 cellular respiration ii. Glycolysis: glucose converted to 2 pyruvate, gain of 2 atp and 2 nadh. Pyruvate oxidation/citric cycle: 2x pyruvate acetyl-coa + co2. Gain of 2 nadh: 2x acetyl-coa co2. Gain of 3 nadh, 1 atp and 1 fadh2 per acetyl-coa. All of remaining energy is in electron carriers nadh and fadh2. Electrons will move down the chain until ultimately reducing o2. This energy will be passed along electron transport chain by a series of redox reactions: o2 is gaining electrons. Electron transport takes place on inner mitochondrial membrane. Complex i, uq, and complex iv pump protons across the membrane. Fadh2 donates to complex ii first (skips complex i: therefore, makes 1/3 less energy than nadh. Complex i transports to complex i first. Not the proteins which are oxidized/reduced: non-protein prosthetic groups, redox active cofactors. Each component has a higher affinity for electrons than preceding carrier: low to high electronegativity, spontaneous down free energy gradient.

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