Biology 1202B Lecture Notes - Lecture 24: Pattern Recognition Receptor, Edward Jenner, Adaptive Immune System
30 Mar 2016
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Biology 1202b lecture 24: defences against disease i. Milkmaids were generally immune to smallpox if they previously had cowpox: similar disease, but less severe. Edward jenner (1796: inoculated an 8 year old boy with cowpox. Caused mild infection: inoculated boy with smallpox. Technique of infecting with a similar but less severe form of pathogen: evolved to modern vaccinations. All take advantage of the immune system. Innate: adaptive immunity (only found in vertebrates) Prevents pathogens from entering the body: physical. Immunity requires an organism to differentiate between self and foreign: must recognize pathogen as foreign, pathogen-associated molecular patterns (pamp) Molecules on outside of the pathogen (e. g. protein in coat) Proteins which recognize and bind to pamp. Inflammation is the first response once the first line has been broken. Leukocytes are the active cells of the immune system. Innate immunity is effective at recognizing bacterial pamps: more difficult to recognize viral pamps. Size of virus smaller than bacterial pamps.
