Biology 1202B Lecture Notes - Lecture 18: Copy-Number Variation, Retrovirus, Metaphase
11 Apr 2016
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Genomics: study of genes and their functions and related techniques. The difference: genetics addresses the single gene, whereas genomics address all genes and their interrelationships. The human genome: 22 autosomes 2 sex chromosomes (xx, xy) o o o. Genetic screening by staining the chromosomes (most compact at metaphase) which will create a banding pattern. See large differences between the karyotype of individuals vs "standard" karyotype. Our knowledge of the human genome in 1990: o o o. Sequence of a number of genes and genomic regions. The human genome project: to sequence and characterize the human genome o o. Transcription factor: compromising the majority of our genes, transcription factors affect the way that our genes are expressed. Hgp and celera (private corporation) published the reference human genome as a consensus. (not the genome of any individual as there are many individual differences) o. Genes that code for proteins compromise 1. 2% of the genome. "gaps in the genome" are still being "filled"
