Biology 3355A/B Lecture Notes - Lecture 1: Arenite, Conformational Change, Hydrolysis
28 Jan 2018
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Hs = 3-5 degrees above normal: cellular response pathway, transient expression of hsp (protect cells from physical & chemical insults) Heat shock hsf enters nucleus hsp proteins formed while inhibit misfolded proteins. How does global heat shock- induce change the cells: discovery of hsr high temp = formation of polytene chromosome puffs. 40s ribosome (light grey oval) scans pass initiation codon of inhibitory uorf2 before requiring new ternary complex: delayed translation reinitiation: delayed acquisition of elf2 ternary complex. = translation initiation at the cds and increase atf4 expression: elf2a-p doesn"t allow elf2 to bind gtp (needed for normal transcription, so, at4 activation with high stress. Chaperones: primary structure amino acid sequence. Chaperonins: folding hydrophobic core, hydrophilic outside, some proteins can self-assemble, secondary structure, a- helix or b-sheet, tertiary structure, formation of small structural motifs (preced formation of stable domains and final tertiatry structure)
