Biology 3597A/B Lecture Notes - Lecture 11: H3K4Me3, Chromatin, Epigenetics
25 Jan 2020
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Document Summary
Methylation = activation and repression depending on the mark: ex. The most common and well-understood histone modifications are acetylation and methylation. Many amino acid residues on histone tails are able to be altered. The different chromatin states are coded by colour. First row = active transcriptional start site (tss: ex. different combos of histone modifications that are indicative of an active start site (active. Strong transcription (indicated by h3k36me3 activating) The entire genome is divided into chromatin states based on these histone modifications. Another way to view chromatin states is through chip-seq raw data. Chip-seq raw data provides us with a different view of chromatin states. Each row indicates the level of a certain protein at that point in the genome (whether or not the proteins are bound to that particular point of the genome or not) Y-axis = different histone modifications (peaks indicate where there are more proteins bound)
