Kinesiology 1070A/B Lecture Notes - Lecture 11: Chronic Traumatic Encephalopathy, Mild Cognitive Impairment, Dementia With Lewy Bodies
27 Feb 2019
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Lecture 11 depression (contd) ; exercise and dementia. Concluded that exercise can be considered an alternative treatment for depression (takes more time than medication) Meta analysis proved that exercise had a small improvement when compared to medication/no treatment (standard mean difference (smd) of -0. 62) Smd of about 0. 6 correlates to 73%; 73% means those who participate in exercise are likely to score better on depression scales than 73% of the control group/those who do not participate in exercise. Depression impairs episodic memory, increases cortisol (impairs function), reduced hippocampal volume; exercise is proven to improve episodic memory and decrease cortisol levels. Kynurenine (kyn) is a chemical that is released during stress, travels to brain where it can cause neuroinflammation, cell death and depression. Exercise causes the production of the kat enzyme, which converts kynurenine into kynurenic acid (kyna), a substance unable to cross the blood-brain barrier.
