Microbiology and Immunology 2500A/B Lecture Notes - Lecture 18: Hiv Vaccine, Envelope Glycoprotein Gp120, Subtypes Of Hiv
20 Feb 2017
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Document Summary
Provirus is a virus genome that is integrated into the dna of a host cell. Rt inhibitors blocks conversion of viral rna genome into single stranded dna: viral replication goes through dna intermediate, azt (zidovudine), 3tc (lamivudine), ddi (didanosine) Protease inhibitors: protease cleaves large precurosor proteins of hiv to functional units, amprenavir, tipranavir, indinavir, ritonavir, atazanavir, nelfinavir, fosamprenvir. Never eliminate persistent infection of hiv because because dna integrates into chromosomal dna. As soon as you stop retroviral therapy, virus production resumes. People taking cart can have a near normal life as it supress esviral production so virus load is very low when they take cart. Ultimate solution would be to get rid of persistently virus-infected cells (the or prevent hiv infections by prophylactic vaccine. Prophylactic to prevent or ameliorate the effects of a future infection by any natural or. Gilead science"s truvada costs up to ,000 a year in the. 90% protection but the cost is very high.
